Feb 17, 2020 Feb 17, 2020
03:30PM 04:30PM Seminar: Beth Buck-Koehntop, University of Utah: Room: Atwood Hall 360University Event Topic: Research,Science,Seminars & WorkshopsDepartment / Organization: Chemistry DepartmentSchool: Emory CollegeHost: Jen HeemstraEvent Contact: kwalsh6@emory.eduCommunity: biomolecular,faculty,graduate,organic,staffLink: https://chem.utah.edu/directory/koehntop/research-group/index.php"Investigating Zinc Finger Regulation of Epigenetically Modified DNA" Bethany A. Buck-Koehntop (she/her/hers), Associate Professor of Chemistry University of Utah, Salt Lake City, UT, USA DNA methylation is an essential epigenetic modification in eukaryotes required for genomic stability, control of gene expression and regulation of chromatin structure. Misappropriation of genomic DNA methylation patterns has a direct link to disease, prompting the need to understand the regulatory mechanisms of DNA methylation in gene transcription. The ZBTB family of methyl-CpG binding proteins (MBPs) consists of three specialized transcription factors which exhibit bimodal DNA recognition by specifically targeting both methylated DNA as well as sequence-specific TpG-containing sites. DNA recognition recruits chromatin remodeling complexes, altering chromatin structure and transcriptional outcomes at the target site. While there are sufficient findings to suggest that transcriptional activities mediated by the ZBTB MBPs are associated with disease, an extensive analysis for the mechanisms of DNA and protein recognition in transcriptional regulation mediated by each protein has yet to be fully examined. To investigate this, our laboratory utilizes an interdisciplinary approach incorporating in vitro biophysical/biochemical and multiple in cell methodologies. This presentation will emphasize how this combined approach provides a powerful platform for beginning to delineate the mechanisms by which these proteins elicit preferential binding selectivity for their biological targets and modulate transcription. + Atwood Hall 360 Campus Events
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03:30PM 04:30PM Seminar: Beth Buck-Koehntop, University of Utah: Room: Atwood Hall 360University Event Topic: Research,Science,Seminars & WorkshopsDepartment / Organization: Chemistry DepartmentSchool: Emory CollegeHost: Jen HeemstraEvent Contact: kwalsh6@emory.eduCommunity: biomolecular,faculty,graduate,organic,staffLink: https://chem.utah.edu/directory/koehntop/research-group/index.php"Investigating Zinc Finger Regulation of Epigenetically Modified DNA" Bethany A. Buck-Koehntop (she/her/hers), Associate Professor of Chemistry University of Utah, Salt Lake City, UT, USA DNA methylation is an essential epigenetic modification in eukaryotes required for genomic stability, control of gene expression and regulation of chromatin structure. Misappropriation of genomic DNA methylation patterns has a direct link to disease, prompting the need to understand the regulatory mechanisms of DNA methylation in gene transcription. The ZBTB family of methyl-CpG binding proteins (MBPs) consists of three specialized transcription factors which exhibit bimodal DNA recognition by specifically targeting both methylated DNA as well as sequence-specific TpG-containing sites. DNA recognition recruits chromatin remodeling complexes, altering chromatin structure and transcriptional outcomes at the target site. While there are sufficient findings to suggest that transcriptional activities mediated by the ZBTB MBPs are associated with disease, an extensive analysis for the mechanisms of DNA and protein recognition in transcriptional regulation mediated by each protein has yet to be fully examined. To investigate this, our laboratory utilizes an interdisciplinary approach incorporating in vitro biophysical/biochemical and multiple in cell methodologies. This presentation will emphasize how this combined approach provides a powerful platform for beginning to delineate the mechanisms by which these proteins elicit preferential binding selectivity for their biological targets and modulate transcription. + Atwood Hall 360 Campus Events
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