May 14, 2021 May 14, 2021
12:00PM 01:00PM 30 years of Molecular Glues: Controlling cell circuitry in biology and medicine: University Event Topic: Lectures & MeetingsDepartment / Organization: PharmacologyBuilding/Room: Virtual RoomMeeting Organizer/Sponsor: Biological Discovery Through Chemical InnovationSpeaker/Presenter: Sturart Schreiber, PhDEvent Open To: All (Public),All StudentsCost: FreeContact Name: Callie WigingtonContact Email: callie.p.wigington@emory.eduAbstract: This year marks the 50th and 35th anniversaries of the reporting of the natural products and immunosuppressants cyclosporin A (CsA; sandimmune) and FK506 (tacrolimus), respectively, and the 30th anniversary of the revelation, published in Cell in 1991, that both compounds act in a way previously not seen – as “molecular glues” that induce protein–protein associations (analogous to peptide molecular glues that induce MHC–T-cell receptor interactions as described in Cell, 1992). On this occasion, and as the realization that additional transformative medicines also act as molecular glues continues to fuel the surge of interest in diverse chemical strategies for inducing functional protein–protein associations, I will explore the arc of this story and present new advances in the discovery of small-molecule binders and molecular glues – new ways to discover molecular glues as stabilizers, degraders and correctors. And new ways to use molecular glues to dissect cell circuitry in biology and medicine, including in tissue- and substrate-selective manners. See: “The Rise of Molecular Glues”, Cell, 2021 + Zoom link: <a href="" target="_blank" rel="noopener" title=" Campus Events
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